Graduate School of Systemic Neurosciences GSN-LMU
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Rainer Glaß

Prof. Dr. Rainer Glaß

GSN associate faculty

Responsibilities

Principal Investigator "Neurosurgical Research"

Contact

Munich University Hospital (LMU)
Dept. Neurosurgery
Marchioninistr. 15
D-81377 Munich

Phone: +49 (0)89 / 4400-73148
Fax: +49 (0)89 / 4400-72051

Website: http://www.hirntumorstammzellen.de
Website: http://www.klinikum.uni-muenchen.de/Neurochirurgische-Klinik-und-Poliklinik/en/research/team_research/01_Glass/index.html

Further Information

Research focus: Neural stem cell and microglia interaction with gliomas

Key words: Neurogenesis, gliomas, angiogenesis, microglia

Selected publications:

Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, St J Smith E, Wend P, Purfürst B, Nuber UA, Gurok U, Matyash V, Wälzlein J-H, Chirasani SR, Dittmar G, Cravatt BF, Momma S, Lewin GR, Ligresti A, De Petrocellis L, Cristino L, Di Marzo V, Kettenmann H and Glass R. (2012) Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1. Nature Medicine doi:10.1038/nm.2827

Chirasani SR, Sternjak A, Wend P, Momma S, Campos B, Herrmann IM, Graf D, Mitsiadis T, Herold-Mende C, Besser D, Synowitz M, Kettenmann H and Glass R. (2010) Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells. Brain 133(7): 1961-72.

Markovic DS, Vinnakota K, Chirasani S, Synowitz M, Raguet H, Stock K, Sliwa M, Lehmann S, Kälin R, van Rooijen N, Holmbeck K, Heppner FL, Kiwit J, Matyash V, Lehnardt S, Kaminska B, Glass R, Kettenmann H. (2009) Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. Proc Natl Acad Sci USA 106(30): 12530-5.

Walzlein J-H, Synowitz M, Engels B, Markovic DS, Gabrusiewicz K, Nikolaev E, Yoshikawa K, Kaminska B, Kempermann G, Uckert W, Kaczmarek L, Kettenmann H and Glass R. (2008) The antitumorigenic response of neural precursors depends on subventricular proliferation and age. Stem Cells 26(11): 2945-54.

Synowitz M, Glass R, Färber K, Markovic D, Kronenberg G, Herrmann K, Schnermann J, Nolte C, van Rooijen N, Kiwit J, Kettenmann H. (2006) A1 adenosine receptors in microglia control glioblastoma-host interaction. Cancer Res 66(17): 8550-7.