Graduate School of Systemic Neurosciences GSN-LMU
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Christian Haass

Prof. Dr. Christian Haass

Regular member MCN, GSN core faculty

Responsibilities

Head of the Laboratory of Neurodegenerative Disease Research (Haass Lab)
Speaker of the Collaborative Research Center 596
Member of the Center for Integrated Protein Science Munich
Speaker of the German Center for Neurodegenerative Diseases (DZNE) - Munich

Contact

Ludwig-Maximilians-University Munich
German Center for Neurodegenerative Diseases (DZNE)
Feodor-Lynenstr. 17,
81337 M√ľnchen

Phone: 089/ 4400 46549
Fax: 089/ 4400 46546

Website: http://www.biochemie.abi.med.uni-muenchen.de/about/staff/professors/haass/index.html
Website: http://www.dzne.de/en/centers/munich/research-groups/haass.html

Further Information

Research focus: Cellular neurobiology, molecular neurobiology

Key words: Alzheimer's and Parkinson's disease, ß-amyloid precursor protein (ßAPP), human cells, yeast, C. elegans, zebrafish, transgenic mouse models, BACE1 and BACE, secretase complex components (Presenilin, Aph-1, Nicastrin, and Pen-2), parkin and DJ-1, intramembraneous cleavage

GSN students

Selected publications:

Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann KH, Haass C and Steiner H. (2011) Attenuated Aβ42 responses to low potency γ-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. J Biol Chem. 286(17):15240-51.

Fleck D, Garratt AN, Haass C and Willem M. (2011) BACE1 Dependent Neuregulin Proteolysis. Curr Alzheimer Res. 2011 May 23.

Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B and Haass C. (2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci. 27(45): 12413-8.

Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C and Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314(5799): 664-6.

Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Bohland C, Imhof A, Martoglio B, Teplow DB and Haass C. (2006) A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol. 8(8): 894-6.