Responsibilities
Research group leader
Contact
der Technischen Universität München
Klinikum rechts der Isar
Trogerstrasse 16
81675 Munich
Phone:
+49 (0)89 / 4140-9839, Lab: +49 (0)89 / 4140-6296
Fax:
+49 (0)89 / 4140-4886
Email:
g.rammes@tum.de
Website:
http://www.anaesth.med.tum.de/node/202
Further Information
Research focus: Learning & Memory, Alzheimer, Mechanisms of Anesthetics, Anxiolytics
Key words: Electrophysiology, long-term potentiation, voltage-sensitive-dye imaging, alzheimer, anesthetics
Current GSN Students: Arpit Kumar Pradhan
Selected publications:
Rammes G, Gravius A, Ruitenberg M, Wegener N, Chambon C, Sroka-Saidi K, Jeggo R, Staniaszek L, Parsons CG (2015) MRZ-99030 - a novel modulator of β-amyloid (Aβ) aggregation reverses Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice. Neuropharmacology 92:170-82
Parsons GP, Ruitenberg M, Freitag CE, Sroka-Saidi K, Russ H, Rammes G (2015) MRZ-99030 – a novel modulator of Aβ aggregation for treating glaucoma and age-related macular degeneration (AMD). Neuropharmacology 92:158-69.
Mattusch C, Kratzer S, Buerge M, Kreuzer M, Engel T, Kopp C, Biel M, Hammelmann V, Ying SW, Goldstein PA, Kochs E, Haseneder R, Rammes G (2015) Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments. Anesthesiology 122(5):1047-59
Kratzer S, Mattusch C, Kochs E, Eder M, Haseneder R, Rammes G (2012) Xenon Attenuates Hippocampal Long-term Potentiation by Diminishing Synaptic and Extrasynaptic N-methyl-D-aspartate Receptor Currents. Anesthesiology 116:673-682
Rupprecht R, Rammes G, Eser D, Baghai TC, Schule C, Nothdurfter C, Troxler T, Gentsch C, Kalkman HO, Chaperon F, Uzunov V, McAllister KH, Bertaina-Anglade V, La Rochelle CD, Tuerck D, Floesser A, Kiese B, Schumacher M, Landgraf R, Holsboer F, Kucher K (2009) Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science 325:490-3.
Domenici MR, Azad SC, Marsicano G, Schierloh A, Wotjak CT, Dodt HU, Zieglgansberger W, Lutz B, Rammes G (2006) Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission. Journal of Neuroscience 26:5794-5799.
Rammes G, Eisensamer B, Ferrari U, Shapa M, Gimpl G, Gilling K, Parsons C, Riering K, Hapfelmeier G, Bondy B, Zieglgansberger W, Holsboer F, Rupprecht R (2004) Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner. Molecular Psychiatry 9:846-858.
Rammes G, Eisensamer B, Gimpl G, Shapa M, Ferrari U, Hapfelmeier G, Bondy B, Parsons C, Gilling K, Zieglgansberger W, Holsboer F, Rupprecht R (2003) Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor. Molecular Psychiatry 8:994-1007.
Marsicano G, Wotjak CT, Rammes G, Azad SC, Bisogno T, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgansberger W, Di Marzo V, Lutz B (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-534.
Rammes G, Sillaber I, Zimmermann S, Mahal B, Zieglgansberger W, Wurst W, Holsboer F, Spanagel R (2002) Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science 296:931-933.