Graduate School of Systemic Neurosciences GSN-LMU
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Stylianos Michalakis

Prof. Dr. Stylianos Michalakis

GSN associate faculty, regular member MCN

Responsibilities

Professor of Ocular Gene Therapy

Contact

Department of Ophthalmology
University Hospital
LMU Munich
Mathildenstr. 8
D-80336 München

Phone: +49 (0)89 / 2180-77325
Fax: +49 (0)89 / 2180-77326

Website: http://www.klinikum.uni-muenchen.de/Augenklinik-und-Poliklinik/de/forschung/gentherapie/english_version/index.html

Further Information

Research focus: Retinal gene therapy, disease mechanisms and neurodegenerative processes in the retina as well as functional characterization of cyclic nucleotide-gated channels in the CNS

Key words: Gene therapy, retinal degeneration, aav vectors, epigenetics, tet enzymes

GSN students:

Selected publications:

Völkner M, Pavlou M, Büning H, Michalakis S#, Karl MO#. (2021) Optimized Adeno-Associated Virus Vectors for Efficient Transduction of Human Retinal Organoids. Hum Gene Ther. June 24 online ahead of print.

Murenu E, Kostidis S, Lahiri S, Geserich AS, Imhof A, Giera M, Michalakis S. (2021) Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice. Int J Mol Sci. 22(5):2345.

Pavlou M, Schön C, Occelli LM, Rossi A, Meumann N, Boyd RF, Bartoe JT, Siedlecki J, Gerhardt MJ, Babutzka S, Bogedein J, Wagner JE, Priglinger SG, Biel M, Petersen-Jones SM, Büning H#, Michalakis S#. (2021) Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders. EMBO Mol Med. 13(4):e13392.

Murenu E, Pavlou M, Richter L, Rapti K, Just S, Cehajic-Kapetanovic J, Tafrishi N, Hayes A, Scholey R, Lucas R, Büning H, Grimm D, Michalakis S. (2021)

Böhm S, Splith V, Riedmayr LM, Rötzer RD, Gasparoni G, Nordström KJV, Wagner JE, Hinrichsmeyer KS, Walter J, Wahl-Schott C, Fenske S, Biel M, Michalakis S, Becirovic E. (2020) A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation. Sci Adv. 6(34):eaba5614.

Fischer MD*, Michalakis S*, Wilhelm B, Zobor D, Muehlfriedel R, Kohl S, Weisschuh N, Ochakovski GA, Klein R, Schoen C, Sothilingam V, Garcia-Garrido M, Kuehlewein L, Kahle N, Werner A, Dauletbekov D, Paquet-Durand F, Tsang S, Martus P, Peters T, Seeliger M, Bartz-

Schmidt KU, Ueffing M, Zrenner E, Biel M*, Wissinger B*. (2020) Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial. JAMA Ophthalmol. 138(6):643-651.

Blank T, Goldmann T, Koch M, Amann L, Schön C, Bonin M, Pang S, Prinz M, Burnet M, Wagner JE, Biel M, Michalakis S. (2018) Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa. Front Immunol. 8:1930.

Perera, A., Eisen D., Wagner, M., Laube, S.K., Künzel, A.F., Koch, S., Steinbacher, J., Schulze, E., Splith, V., Splith, V., Mittermeier, N., Müller, M., Biel, M., Carell, T., Michalakis, S. (2015). TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression. Cell Rep. 11(2):283-94.

Koch, S., Sothilingam, V., Garcia Garrido, M., Tanimoto, N., Becirovic, E., Koch, F., Seide, C., Beck, S.C., Seeliger, M.W., Biel, M., Mühlfriedel, R., and Michalakis, S. (2012). Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Hum Mol Genet. 21:4486-4496.

Michalakis, S., Zong, X., Becirovic, E., Hammelmann, V., Wein, T., Wanner, K.T., and Biel, M. (2011). The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels. J Neurosci. 31:133-141.

Michalakis, S., Mühlfriedel, R., Tanimoto, N., Krishnamoorthy, V., Koch, S., Fischer, M.D., Becirovic, E., Bai, L., Huber, G., Beck, S.C., et al. (2010). Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function. Mol Ther. 18:2057-2063.