Graduate School of Systemic Neurosciences GSN-LMU
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PD Dr. Conny Kopp-Scheinpflug

GSN associate faculty, GSN Women's Representative (Frauenbeauftragte), GSN Scientific Board member

Responsibilities

Research group leader "Function and Mechanisms of activity-dependent Neuromodulation"

GSN women´s representative: offers advice regarding female-oriented matters (i. e. career planning, support programs and grants, work-life balance).

Contact

Division of Neurobiology
Department Biology II
Ludwig-Maximilians-Universität München
Großhaderner Straße 2
D-82152 Planegg-Martinsried

Room: B03.026
Phone: +49 (0)89 / 2180-74310
Fax: +49 (0)89 / 2180-74168

Website: http://neuro.bio.lmu.de/research_groups/res-kopp-scheinpflug_c/index.html

Further Information

Research focus:

Function and Mechanisms of activity-dependent Neuromodulation Neurons are perfectly tuned to congregate biologically relevant information from synaptic inputs. This process is under permanent activity-dependent control mediated by neuromodulators, which can temporarily sway the neural processing by changing the properties of the membrane receptors, transporters and ion channels involved in synaptic transmission and neuronal excitability. Our laboratory is interested in how ambient sensory stimulation activates neuromodulators and how these then influence the processing of relevant information. We use the mammalian auditory system as a model and apply a variety of electrophysiological (single cell in vivo and patch clamp in brain slices), anatomical and optogentic techniques to study how hyper- or hypo stimulation lead to acquisition/loss of function. We hope that knowing more about these mechanisms will reveal new targets for the treatment of functional disorders of neuronal excitability.

Key words: Neuromodulation, patch-clamp, in vivo recordings, auditory system

Current GSN students: Ezhilarasan Rajaram, Sara Pagella

Selected publications:

Kopp-Scheinpflug C, Tozer AJ, Robinson SW, Tempel BL, Hennig MH and Forsythe ID. (2011) The sound of silence: ionic mechanisms encoding sound termination. Neuron 71(5):911-25. doi: 10.1016/j.neuron.2011.06.028. PubMed PMID: 21903083.

Steinert JR, Robinson SW, Tong H, Haustein MD, Kopp-Scheinpflug C and Forsythe ID. (2011) Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability. Neuron 71(2): 291-305. doi:
10.1016/j.neuron.2011.05.037. PubMed PMID: 21791288; PubMed Central PMCID: PMC3245892.

Kopp-Scheinpflug C, Steinert JR and Forsythe ID. (2011) Modulation and control of synaptic transmission across the MNTB. Hear Res. 279(1-2): 22-31. doi: 10.1016/j.heares.2011.02.007. PubMed PMID: 21397677.

Johnston J, Forsythe ID and Kopp-Scheinpflug C. (2010) Going native: voltage-gated potassium channels controlling neuronal excitability. J Physiol. 588(17): 3187-200. doi: 10.1113/jphysiol.2010.191973. PubMed PMID: 20519310; PubMed Central PMCID: PMC2976014.

Steinert JR, Kopp-Scheinpflug C, Baker C, Challiss RA, Mistry R, Haustein MD, Griffin SJ, Tong H, Graham BP and Forsythe ID. (2008) Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse. Neuron 60(4): 642-56. doi: 10.1016/j.neuron.2008.08.025. PubMed PMID: 19038221.