Graduate School of Systemic Neurosciences GSN-LMU

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Osborne Almeida

Dr. Osborne Almeida

GSN associate faculty


Research group leader


Max Planck Institute of Psychiatry
RG Almeida: Neuroadaptations
Kraepelinstr. 2
D-80804 Munich

Phone: +49 (0)89 / 30622-216
Fax: +49 (0)89 / 30622-461


Further Information

Research focus:Neuroadaptations

Key words: Ageing, stress, nuclear receptors, epigenetics, Alzheimers disease

Graduated GSN students: Dr. Este Leidmaa

Selected publications:

Sotiropoulos I, Catania C, Pinto LG, Silva R, Pollerberg GE, Takashima A, Sousa N and Almeida OFX. (2011) Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits. J Neurosci 31:7840-7847.

Roselli F, Livrea P and Almeida OFX. (2011) CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS One 6:e23097.

Yu S, Patchev AV, Wu Y, Lu J, Holsboer F, Zhang JZ, Sousa N and Almeida OFX. (2010) Depletion of the neural precursor cell pool by glucocorticoids. Ann Neurol 67:21-30.

Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmühl Y, Fischer D, Holsboer F, Wotjak CT, Almeida OFX and Spengler D. (2009) Dynamic DNA methylation pograms persistent adverse effects of early-life stress. Nat Neurosci 12:1559-1566.

Bessa JM, Ferreira D, Melo I, Marques F, Cerqueira JJ, Palha JA, Almeida OFX and Sousa N. (2009) The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Mol Psychiatry14:764-773.

Cerqueira JJ, Mailliet F, Almeida OFX, Jay TM and Sousa N. (2007) The prefrontal cortex as a key target of the maladaptive response to stress. J Neurosci 27:2781-2787.