Research group leader
Research focus: We are interested in genetic risk factors associated with neuropsychiatric disorders, their interaction with environmental exposures and the question how these translate into persistent epigenetic signatures. Moreover, we are intrigued by neural circuits conveying an adaptive stress response and their disturbances underlying pathological conditions.
Key words: Stress, Psychiatric disorders, Neuropeptides, Gene x environment interaction, genetic mouse models
Henckens MJ, Deussing JM, Chen A. (2016) Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. Nat Rev Neurosci. 17(10):636-51.
Bender J, Engeholm M, Ederer MS, Breu J, Møller TC, Michalakis S, Rasko T, Wanker EE, Biel M, Martinez KL, Wurst W, Deussing JM. (2015) Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. PLoS One. 10(9):e0136768. doi: 10.1371/journal.pone.0136768.
Deussing JM. (2013)Targeted mutagenesis tools for modelling psychiatric disorders. Cell Tissue Res. 354(1):9-25. doi: 10.1007/s00441-013-1708-5.
Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM. (2011) Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science. 333(6051):1903-7. doi: 10.1126/science.1202107.