Graduate School of Systemic Neurosciences GSN-LMU
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David Keays

Prof. Dr. David Keays

GSN associate faculty

Responsibilities

Chair of Organismal and Developmental Neurobiology

Contact

Ludwig-Maximilians-Universität München
D-82152 Planegg-Martinsried


Website: keayslab.org

Further Information

Research focus: Magnetoreception, electroreception, neuronal circuits, genetic basis of neurode-velopmental disease, microtubules.

Key Words: Pigeons, mice, cerebral organoids, whole brain imaging, light sheet mi-croscopy, 2-photon microscopy.

Selected publications:

Hochstoeger T, Al Said T, Maestre D, Walter F, Vilceanu A, Pedron M, Cushion TD, Snider W, Nimpf S, Nordmann GC, Landler L, Edelman N, Kruppa L, Dürnberger G, Mechtler K, Schuechner S, Ogris E, Malkemper EP, Weber S, Schleicher E, Keays DA. The biophysical, molecular, and anatomical landscape of pigeon CRY4: a candidate light based quantal magnetosensor. Science Advances, 2020 in press.

Nimpf S, Nordmann GC, Kagerbauer D, Malkemper EP, Landler L, Papadaki-Anastasopoulou A, Ushakova L, Wenninger-Weinzierl A, Novatchkova M, Vincent P, Lendl T, Colombini M, Mason MJ, Keays DA. A putative mechanism for magnetoreception by electromagnetic induction in the pigeon inner ear. Current Biology. 2019 Dec 2;29(23):4052-4059.

Tripathy R, van Dijk T, van Bon B, Gstrein T, Bahi-Buisson N, Paciorkowski A, Pagnamenta A, Taylor J, Terrone G, Vitiello G, D’Amico A, Del Giudice E, Brunetti-Pierri N, Reymond A, Voisin N, Bernstein JA, Farrelly E, Pierson T, Kini U, Leonard T, Mirzaa G, Baas F, Chelly J, Keays DA Mutations in MAST1 cause mega corpus callosum syndrome and cortical malformations. Neuron, 2018 Dec 19;100(6):1354-1368.

Gstrein T, Edwards A, Přistoupilová A, Leca I, Breuss M, Pilat-Carotta S, Hansen AH, Tripathy R, Traunbauer AK, Hochstoeger T, Rosoklija G, Repic M, Landler L, Stránecký V, Dürnberger G, Keane TM, Zuber J, Adams DJ, Flint J, Honzik T, Gut M, Beltran S, Mechtler K, Sherr E, Kmoch S, Gut I, Keays DA. (2018). Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in hu-mans. Nature Neuroscience. Feb;21(2):207-217.

Treiber CD, Salzer CM, Riegler J, Edelman N, Sugar C, Breuss M, Pichler P, Cadiou H, Saunders M, Lythgoe M, Shaw J, Keays DA. Clusters of iron rich cells in the upper beak of pigeons are macrophages not magnetosensi-tive neurons. Nature. 2012 Apr 11;484(7394):367-70.

Keays DA, Tian G, Poirier K, Huang G, Siebold S, Cleak J, Oliver P, Washbourne R, Fray M, Harvey RJ, Molnar Z, Pinon M, Dear N, Brown SD, Rawlins JP, Davies KE, Cowan NJ, Patrick Nolan P, Chelly J, Flint J. Mutations in -tubulin cause defects in neuronal migration in mice and lissencephaly in humans. Cell. 2007 Jan 12;128(1):45-57.