Graduate School of Systemic Neurosciences GSN-LMU
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Stefan Lichtenthaler

Prof. Dr. Stefan Lichtenthaler

GSN associate faculty, regular member MCN

Responsibilities

Professor TU Munich, Group Leader DZNE

Contact

German Center for Neurodegenerative Diseases (DZNE)
and Technische Universität München (TUM)
Feodor-Lynen-Strasse 17
81377 Munich
Germany

Phone: +49 (0)89 / 4400-46425 (Assistant: -46426)
Fax: +49 (0)89 / 4400-46429

Website: http://www.professoren.tum.de/en/lichtenthaler-stefan/
Website: http://www.dzne.de/en/sites/munich/research-groups/lichtenthaler.html

Further Information

Research focus: Neurodegeneration, proteases, neuroproteomics

Key words: Alzheimer’s disease, regulated intramembrane proteolysis, quantitative mass spectrometry, secretome analysis, BACE proteases

Current GSN students: Martina Pigoni, Andree Schmidt

Selected publications:

Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF (2016). Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. eLife 5, e12748.

Dislich B, Wohlrab F, Bachhuber T, Mueller S, Kuhn PH, Hogl S, Meyer-Luehmann M, Lichtenthaler SF (2015). Label-free quantitative proteomics of mouse cerebrospinal fluid detects BACE1 protease substrates in vivo. Mol Cell Proteomics 14, 2550-2563.

Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2015). γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nat Communic 6, 7333.

Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers S, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF (2012). Secretome Protein Enrichment with Click Sugars Identifies Physiological Substrates of the Alzheimer Protease BACE1 in Primary Neurons. EMBO J 31, 3157-3168.

Lichtenthaler SF (2012). Cell Biology: Sheddase Gets Guidance. Science 335, 179-180.

Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Roßner S, Lichtenthaler SF (2010). ADAM10 is the Physiologically Relevant, Constitutive Alpha-Secretase of the Amyloid Precursor Protein in Primary Neurons. EMBO J 29, 3020-3032.