Responsibilities
Professor TU Munich, Group Leader DZNE
Contact
and Technische Universität München (TUM)
Feodor-Lynen-Strasse 17
81377 Munich
Germany
Phone:
+49 (0)89 / 4400-46425 (Assistant: -46426)
Fax:
+49 (0)89 / 4400-46429
Email:
stefan.lichtenthaler@dzne.de
Website:
http://www.professoren.tum.de/en/lichtenthaler-stefan/
Website:
http://www.dzne.de/en/sites/munich/research-groups/lichtenthaler.html
Further Information
Research focus: Neurodegeneration, proteases, neuroproteomics
Key words: Alzheimer’s disease, regulated intramembrane proteolysis, quantitative mass spectrometry, secretome analysis, BACE proteases
- Current GSN students: Andree Schmidt, Laura Hoffmann
- Graduated GSN students: Dr. Martina Pigoni
Selected publications:
Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF (2016). Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. eLife 5, e12748.
Dislich B, Wohlrab F, Bachhuber T, Mueller S, Kuhn PH, Hogl S, Meyer-Luehmann M, Lichtenthaler SF (2015). Label-free quantitative proteomics of mouse cerebrospinal fluid detects BACE1 protease substrates in vivo. Mol Cell Proteomics 14, 2550-2563.
Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2015). γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nat Communic 6, 7333.
Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers S, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF (2012). Secretome Protein Enrichment with Click Sugars Identifies Physiological Substrates of the Alzheimer Protease BACE1 in Primary Neurons. EMBO J 31, 3157-3168.
Lichtenthaler SF (2012). Cell Biology: Sheddase Gets Guidance. Science 335, 179-180.
Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Roßner S, Lichtenthaler SF (2010). ADAM10 is the Physiologically Relevant, Constitutive Alpha-Secretase of the Amyloid Precursor Protein in Primary Neurons. EMBO J 29, 3020-3032.