Graduate School of Systemic Neurosciences GSN-LMU

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Hans-Walter Pfister

Prof. Dr. Hans-Walter Pfister

GSN associate faculty


Acting Director of the Clinic


Ludwig-Maximilians-University Munich
University Clinic Großhadern
Neurological Clinic
Marchioninistr. 15
D-81377 Munich

Phone: +49 (0)89 / 4400-72560
Fax: +49 (0)89 / 4400-75561


Further Information

Research focus:

1. Infections of the central nervous system

2. Mechanisms of traumatic brain injury

3. Intensive care neurology (e.g., treatment of increased intracranial pressure, surgical decompression in space-occupying brain infarction)

4. Pathophysiology of Parkinson’s disease and amyotrophic lateral sclerosis

5. Role of angiogenesis (and antiangiogenetic treatment strategies) in glioblastoma

Key words:

1) Cell culture systems (e.g., cerebal endothelial cells, astrocytes, human granulocytes, macrophages)

2) Models of experimental meningitis, amyotrophic lateral sclerosis, cold-induced brain injury

3) Measurement of cerebral blood flow using laser-doppler flowmetry, monitoring of intracranial pressure and blood-brain barrier permeability

4) RT-PCR, immunohistochemistry, Western-blot, chemiluminescence, zymography, histology

Selected publications:

Kastenbauer S and Pfister HW. (2003) Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain 126: 1015-1025.

Koedel U, Angele B, Rupprecht T, Wagner H, Roggenkamp A, Pfister HW and Kirschning CJ. (2003) Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 170: 438-444.

Koedel U, Winkler F, Angele B, Fontana A, Flavell RA and Pfister HW. (2002) Role of Caspase-1 in experimental pneumococcal meningitis: evidence from pharmacologic caspase inhibition and Caspase-1 deficient mice. Ann Neurol 51: 319-329.

Eugster HP, Frei K, Winkler F, Koedel U, Pfister W, Lassmann H and Fontana A. (2001) Superantigen overcomes resistance of IL-6-deficient mice towards MOG-induced EAE by a TNF-R1 controlled pathway. Eur J Immunol 31: 2302-2312.

Koedel U, Kohleisen B, Sporer B, Fontana A, Erfle V and Pfister HW. (1999) HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system. J Immunol 163: 1237-1245.