Graduate School of Systemic Neurosciences GSN-LMU
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Christian Wahl-Schott

Prof. Dr. Christian Wahl-Schott

GSN associate faculty

Responsibilities

Professor for Molecular Pharmacology

Contact

Department Pharmacy
Center for Drug Research, LMU
Butenandtstrasse 7-13, Haus C
D-81377 Muenchen

Phone: +49 (0)89 / 2180-77654

Website: http://www.pharmacology.cup.unimuenchen. de/prof_wahl/index.html

Further Information

Research focus : TPC and HCN channels in the central nervous system lysosomal patch clamp FRET

Keywords: Septohippocampal system axonal transport HCN and TPC channels endo-lysosomal ion channels lysosomal patch clamp

Selected publications:

Butz E, Ben-Johny M, Shen M, Yang P, Sang L, Biel M, Yue DT, and Wahl-Schott C. (2016) Quantifying Macromolecular Interactions in Living cells using FRET 2-hybrid Assays. Nature protocols 11:2470-2498.

Becirovic E, Boehm S, Nguyen P, Riedmayr LM, Hammelmann V, Schön C, Butz ES, Wahl-Schott C, Biel M and Michalakis S. (2016) AAV vectors for FRET-based analysis of protein-protein interactions in photoreceptor outer segments. Front. Neurosci. doi: 10.3389/fnins.2016.00356

Fenske S., Pröbstle R., Auer F., Hassan S., Marks V., Pauza DH., Biel M., Wahl-Schott C. (2016) Comprehensive Multi-level in vivo and in vitro Analysis of Heart Rate Fluctuations in Mice by ECG Telemetry and Electrophysiology. Nature protocols 11:61-86.

Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA. (2015) Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science 347:995-8.

Grimm C, Holdt LM, Chen CC, Hassan S, Muller C, Jors S, Cuny H, Kissing S, Schroder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lullmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C. (2014) High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nature communications 5:4699.

Chen CC, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C. (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nature communications 5:4681.

Fenske S, Krause SC, Hassan SI, Becirovic E, Auer F, Bernard R, Kupatt C, Lange P, Ziegler T, Wotjak CT, Zhang H, Hammelmann V, Paparizos C, Biel M, Wahl-Schott CA. (2013) Sick sinus syndrome in HCN1-deficient mice. Circulation 128:2585-2594.

Wahl-Schott C, Baumann L, Cuny H, Eckert C, Griessmeier K, Biel M. (2006) Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain. Proceedings of the National Academy of Sciences of the United States of America 103:15657-15662.