Dr. Sabine Liebscher

Research focus: circuits in CNS disorders, Neurodegeneration

Keywords: Amyotrophic lateral sclerosis, autoimmune encephalitis, Alzheimer’s disease, in vivo two-photon imaging, virtual reality, single cell transcriptomics, cell-type specific proteomics

GSN students: Pavel Svehla, Wing Yin Vanessa Kan, Zeynep Günes, Christopher Douthwaite, Shenyi Jiang

Selected publications:

Korzhova V, Marinkovic P, Rudan Njavro J, Goltstein PM, Sun F, Tahirovic S, Herms J, Liebscher S (2021). Long-term dynamics of aberrant neuronal activity in awake Alzheimer’s disease transgenic mice. Communications Biology

Blumstock S, Sun F, Klaus C, Marinkovic P, Sgobio C, Paeger L, Liebscher S* & Herms J* (2021). Cortical circuit dysfunction in a mouse model of alpha-synucleinopathy in vivo. Brain Communications * co-author

Scekic-Zahirovic J, Sanjuan-Ruiz I, Kan V, Megat S, De Rossi P, Dieterle S, … Liebscher, S* and Dupuis, L* (2021). Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects. Nat Commun 12: 3028 * co-author

Steffens H, Mott AC, Li S, Wegner W, Svehla P, Kan VWY, Wolf F, Liebscher S*, Willig KI* (2021). Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity. Science Advances 7 * co-author

d'Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezo C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M (2021). Microglia contribute to the propagation of Abeta into unaffected brain tissue. Nat Neurosci.

Gunes ZI, Kan VWY, Ye X, Liebscher S (2020). Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology. Front Neurosci 14:573.

Burgold J, Schulz-Trieglaff EK, Voelkl K, Gutierrez-Angel S, Bader JM, Hosp F, Mann M, Arzberger T, Klein R*, Liebscher S*, Dudanova I* (2019). Cortical circuit alterations precede motor impairments in Huntington's disease mice. Sci Rep 9:6634. * co-author

Cai R et al. (2019). Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections. Nat Neurosci 22:317-327.

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hubener M (2016). Selective Persistence of Sensorimotor Mismatch Signals in Visual Cortex of Behaving Alzheimer's Disease Mice. Curr Biol 26:956-964.

Liebscher S, Page RM, Kafer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Basi GS, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hubener M (2014). Chronic gamma-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Mol Psychiatry 19:937-946.

McCarter JF, Liebscher S, Bachhuber T, Abou-Ajram C, Hubener M, Hyman BT, Haass C, Meyer-Luehmann M (2013). Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathol 126:179-188.