Graduate School of Systemic Neurosciences GSN-LMU
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Ali Ertürk

Dr. Ali Ertürk

GSN associate faculty

Responsibilities

Independent research group leader
Acute Brain Injury Research Group

Contact

Institute for Stroke and Dementia Research (ISD)
Feodor-Lynen-Strasse 17
81377, Munich

Phone: +49 (0)89 / 4400-46240
Fax: +49 (0)89 / 4400-46116

Website: http://www.klinikum.uni-muenchen.de/Institut-fuer-Schlaganfall-und-Demenzforschung/en/research/AcuteBrainInjury/index.html

Further Information

Research focus: We are interested in understanding cellular and molecular mechanisms leading to chronic neurodegeneration after traumatic brain injury. To this end, we use leading-edge imaging technologies including 3D imaging of the entire transparent brains. Our main goal is to develop breakthrough approaches to treat consequences of acute injuries in the CNS.

Key words: synapse/spine elimination, optogenetics, non-apoptotic caspase function, traumatic brain injury, neurodegeneration, neuroinflammation, brain mapping, tissue clearing, light-sheet microscopy, 3DISCO, CLARITY

Current GSN students: Chenchen Pan, Ruiyao Cai

Selected publications:

Pan, C., Cai, R., Quacquarelli, F.P., Ghasemigharagoz, A., Lourbopoulos, A., Matryba, P., Plesnila, N., Dichgans, M., Hellal, F., and Ertürk, A. (2016). Shrinkage-mediated imaging of entire organs and organisms using uDISCO. Nature Methods (Cover of October 2016 Nat Methods issue)

*Ertürk A, Mentz S, Stout E et al. (2016). Interfering with the Chronic Immune Response Rescues Chronic Degeneration After Traumatic Brain Injury. J of Neuroscience . *Corresponding author.

*Ertürk A, Wang Y and *Sheng M. (2014). Local pruning of sendrites and spines by caspase-3-dependent and proteasome-limited mechanisms. J of Neuroscience. *Co-corresponding author.

Chen Y, Wang Y, Ertürk A, Kollap D, Jiang D, Weimer R, Kaminker J and Sheng M. Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in CA1 pyramidal neurons. Neuron (2014).

*Ertürk A, Becker K, Jaehrling N, Mauch CP, Hojer CD, Egen J, et al. (2012): Three-dimensional imaging of solvent cleared organs using 3DISCO. Nature Protocols Oct 11;7(11):1983-95 (Cover article of the 2012 November Nature issue). *Corresponding author.

Ertürk A, Mauch C.P., Hellal F., Forstner F., Keck T., Becker K., Jahrling N., Steffens H., Richter M., Hubener M., et al. (2012): Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nature Medicine 18, 166-171. (Cover article of the 2012 January Nature Medicine issue).

Ylera B*, Ertürk A*, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F (2009): Chronically injured adult sensory axons in the CNS acquire regenerative competence following a lesion of their peripheral process. Current Biology. *Co-first author.

Ertürk A, Hellal F, Enes J, Bradke F (2007): Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration. J of Neuroscience