Graduate School of Systemic Neurosciences GSN-LMU

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Arthur Liesz

Prof. Dr. Arthur Liesz

GSN associate faculty


Research group leader


Institute for Stroke and Dementia Research (ISD)


Further Information

Keywords: Stroke | Neuroinflammation | Recovery

Brief research description: We are interested in the interplay between the brain and the immune system after stroke. Acute brain lesions disturb the well-balanced interconnection between both systems. Hence, our research focuses on both directions of brain-immune interaction: The impact of immune mechanisms on neuronal damage and recovery and the systemic immunomodulation after stroke. Our methodological spectrum covers diverse brain ischemia models, transgenic animal models, a broad spectrum of cutting-edge immunological techniques as well as histological, biomolecular and behavioral analysis tools. The lab has a strong translational research focus with the ultimate goal to develop novel diagnostic tools, therapies and mechanistic insights on the highly complex disease which stroke represents. In order to achieve this, a premise of our work is to address key unmet needs of stroke patients and make use of translationally relevant tools.

Current and graduated GSN students: Alessio Ricci, Kelsey Pinkham, Olga Carofiglio, Dr. Rebecca Sadler

Selected publications:

Heindl S, Ricci A, Carofiglio O, Zhou Q, Arzberger T, Lenart N, Franzmeier N, Hortobagyi T, Nelson PT, Stowe AM, Denes A, Edbauer D, Liesz A. (2021) Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. Journal of Experimental Medicine Aug 2;218(8):e20202411

Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A. (2021) Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity Mar 1;S1074-7613(21)00070-4

Roth S, Singh V, Tiedt S, [...]Bianchi ME, Vivien D, Bernhagen J, Dichgans M, Liesz A (2018) Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. Science Translational Medicine, Mar 14;10(432).

Llovera G, Hoffmann K, Roth S, Salas-Perdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simioni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A (2015) Results of the First Preclinical Randomized Controlled (pRCT) Multicenter Trial: Anti-CD49d treatment for acute brain ischemia. Science Translational Medicine 5;7(299)

Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, Giese T, Veltkamp R (2009) Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nature Medicine 15,192-199