Graduate School of Systemic Neurosciences GSN-LMU
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Nikolaus Plesnila

Prof. Dr. Nikolaus Plesnila

GSN associate faculty

Responsibilities

Professor of Experimental Stroke Research, PI/Head of laboratory

Contact

Institut für Schlaganfall- und Demenzforschung (ISD)
Klinikum der Universität München
Feodor-Lynen-Straße 17
D-81377 München

Phone: +49 (0)89 / 4400-46219 or -46220
Fax: +49 (0)89 / 4400-46113

Website: http://www.klinikum.uni-muenchen.de/Institut-fuer-Schlaganfall-und-Demenzforschung/en/research/Experimental_Stroke_Research/index.html

Further Information

Research focus:Pathophysiology of ischemic and hemorrhagic stroke as the basis for the development of novel therapeutic options for stroke patients

Key words: Experimental stroke models (transient & permanent focal cerebral ischemia, global ischemia, subarachnoid hemorrhage), methodologies to investigate cerebral microcirculation (intravital microscopy using conventional and 2-photon excitation), neurovascular stress, degeneration („vasculodegeneration“), acute and chronic stroke syndromes, pathophysiology of microcirculatory dysfunction, small vessel disease

Current GSN students: Susana Valero Freitag, Bernhard Groschup

Selected publications: Dr. Matilde Balbi, Dr. Kathrin Schüller

Pan C, Cai R, Quacquarelli FP, Ghasemi A, Lourbopoulos A, Matryba P, Hellal F, Dichgans M, Plesnila N, Ertürk A (2016) Shrinkage microscopy mediated imaging of intact organs and organisms. Nature Methods 13(10):859-67

Schwarzmaier SM, de Chaumont C, Balbi M, Kleinschnitz C, Gruber A, Plesnila N (2016) The Formation of Microthrombi in Parenchymal Microvessels after Traumatic Brain Injury Is Independent of Coagulation Factor XI. J Neurotrauma 33(17):1634-1644

Balbi M*, Koide M*, Schwarzmaier SM, Wellman GC*, Plesnila N* (2016) Acute changes in neurovascular reactivity after subarachnoid hemorrhage in vivo. J Cereb Blood Flow Metab 37(1):178-187

Meissner L*, Balbi*, Gallozzi M, Schwarzmaier S, Terpolilli N, Plesnila N (2016). Temporal profile of microRNA expression in contused cortex following experimental traumatic brain injury J Neurotrauma 33(8):713-20

Ghosh M*, Balbi M*, Dichgans M, Lindauer U*, Plesnila N* (2015). Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Ann Neurol 78:887-900

Terpolilli N, Brem C, Bühler D, Plesnila N (2015) Are we barking up the wrong vessels? Current views on the pathogenesis of subarachnoid hemorrhage. Stroke 46:3014-3019

Hockel K, Trabold R, Schöller K, Török E and Plesnila N. (2012)  Impact of anesthesia on pathophysiology and mortality following subarachnoid hemorrhage in rats. Exp Transl Stroke Med 4: 1. 03.

Plesnila N. (2012)  Paving the road to translation. Cerebrovasc Dis 33: 4. 02.

Terpolilli NA, Moskowitz MA and Plesnila N. (2012)  Nitric oxide: considerations for the treatment of ischemic stroke. J Cereb Blood Flow Metab 32: 7. 1332-1346.

Terpolilli NA, Kim S-W, Thal SC, Kataoka H, Zeisig V, Nitzsche B, Klaesner B, Zhu C, Schwarzmaier S, Meissner L, Mamrak U, Engel DC, Drzezga A, Patel RP, Blomgren K, Barthel H, Boltze J, Kuebler WM and Plesnila N. (2012)  Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles. Circ Res 110: 5. 727-738.

Hockel K, Schöller K, Trabold R, Nussberger J and Plesnila N. (2012)  Vasopressin V(1a) receptors mediate posthemorrhagic systemic hypertension thereby determining rebleeding rate and outcome after experimental subarachnoid hemorrhage. Stroke 43: 1. 227-232.