Graduate School of Systemic Neurosciences GSN-LMU
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Gerhard Rammes

Prof. Dr. Gerhard Rammes

MCN advisory Board member, GSN associate faculty

Responsibilities

Research group leader

Contact

Klinik für Anaesthesiologie
der Technischen Universität München
Klinikum rechts der Isar
Trogerstrasse 16
81675 Munich

Phone: +49 (0)89 / 4140-9839, Lab: +49 (0)89 / 4140-6296
Fax: +49 (0)89 / 4140-4886

Website: http://www.anaesth.med.tum.de/node/202

Further Information

Research focus: Learning & Memory, Alzheimer, Mechanisms of Anesthetics, Anxiolytics

Key words: Electrophysiology, long-term potentiation, voltage-sensitive-dye imaging, alzheimer, anesthetics

Current GSN students:

Selected publications:

Rammes G, Gravius A, Ruitenberg M, Wegener N, Chambon C, Sroka-Saidi K, Jeggo R, Staniaszek L, Parsons CG (2015) MRZ-99030 - a novel modulator of β-amyloid (Aβ) aggregation reverses Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice. Neuropharmacology 92:170-82

Parsons GP, Ruitenberg M, Freitag CE, Sroka-Saidi K, Russ H, Rammes G (2015) MRZ-99030 – a novel modulator of Aβ aggregation for treating glaucoma and age-related macular degeneration (AMD). Neuropharmacology 92:158-69.

Mattusch C, Kratzer S, Buerge M, Kreuzer M, Engel T, Kopp C, Biel M, Hammelmann V, Ying SW, Goldstein PA, Kochs E, Haseneder R, Rammes G (2015) Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments. Anesthesiology 122(5):1047-59

Kratzer S, Mattusch C, Kochs E, Eder M, Haseneder R, Rammes G (2012) Xenon Attenuates Hippocampal Long-term Potentiation by Diminishing Synaptic and Extrasynaptic N-methyl-D-aspartate Receptor Currents. Anesthesiology 116:673-682

Rupprecht R, Rammes G, Eser D, Baghai TC, Schule C, Nothdurfter C, Troxler T, Gentsch C, Kalkman HO, Chaperon F, Uzunov V, McAllister KH, Bertaina-Anglade V, La Rochelle CD, Tuerck D, Floesser A, Kiese B, Schumacher M, Landgraf R, Holsboer F, Kucher K (2009) Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science 325:490-3.

Domenici MR, Azad SC, Marsicano G, Schierloh A, Wotjak CT, Dodt HU, Zieglgansberger W, Lutz B, Rammes G (2006) Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission. Journal of Neuroscience 26:5794-5799.

Rammes G, Eisensamer B, Ferrari U, Shapa M, Gimpl G, Gilling K, Parsons C, Riering K, Hapfelmeier G, Bondy B, Zieglgansberger W, Holsboer F, Rupprecht R (2004) Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner. Molecular Psychiatry 9:846-858.

Rammes G, Eisensamer B, Gimpl G, Shapa M, Ferrari U, Hapfelmeier G, Bondy B, Parsons C, Gilling K, Zieglgansberger W, Holsboer F, Rupprecht R (2003) Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor. Molecular Psychiatry 8:994-1007.

Marsicano G, Wotjak CT, Rammes G, Azad SC, Bisogno T, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgansberger W, Di Marzo V, Lutz B (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-534.

Rammes G, Sillaber I, Zimmermann S, Mahal B, Zieglgansberger W, Wurst W, Holsboer F, Spanagel R (2002) Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science 296:931-933.