Graduate School of Systemic Neurosciences GSN-LMU

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Igor Yakushev

PD Dr. Igor Yakushev

GSN associate faculty


Head of Neuroimaging, Dept. of Nuclear Medicine, Technical University of Munich

Principle Investigator, Neuroimaging Center at the Technical University of Munich (TUM-NIC)


Klinik für Nuklearmedizin der
Technischen Universität München
Ismaninger Str. 22
81675 München

Phone: +49 (0) 89-4140-6714
Fax: +49 (0) 89-4140-6719

Further Information

Research focus:

I lead the research group “multimodal imaging of normal and pathological cognition”. Our major clinical focus is neurodegenerative disorders, especially dementia. Here, our ultimate aim is to develop imaging-based biomarkers for routine clinical settings as well as for clinical trials. From the methodological point of view we rely on the concept of brain connectivity. We also investigate imaging correlates of normal cognitive function such as working memory. Our main research method is positron emission tomography; further methods are structural, functional MRI, diffusion tensor imaging, and multimodal imaging.

Keywords: Neuroimaging, neurodegeneration, proteinopathies, biomarkers, cognitive impairment, dementia, neural plasticity, PET, multimodal imaging, brain connectivity

Current GSN Students: Isabelle Ripp

Selected publications:

Savio AM, Schutte M, Grana M, Yakushev I. (2017) Pypes: workflows for processing multimodal neuroimaging data. Frontiers in Neuroinformatics 11:25.

Savio A, Fünger S, Tahmasian M, Rachakonda S, Manoliu A, Sorg C, Grimmer T, Calhoun V, Drzezga A, Riedl V, Yakushev I. (2017) Resting state networks as simultaneously measured with fMRI and PET. Journal of Nuclear Medicine ; in press.

Guo T, Brendel M, Grimmer T, Rominger A, Yakushev I. (2017) Predicting regional pattern of longitudinal beta-amyloid accumulation by baseline positron emission tomography. Journal of Nuclear Medicine 58:639-645.

Titov D, Diehl-Schmid J, Shi K, Perneczky R, Zou N, Grimmer T, Li J, Drzezga A, Yakushev I. (2017) Metabolic connectivity for differential diagnosis of dementing disorders. Journal of Cerebral Blood Flow & Metabolism 37:252-262.

Alexopoulos P, Kriett L, Haller B, Klupp E, Gray K, Grimmer T, Förster S, Perneczky R, Kurz A, Drzezga A, Fellgiebel A, Yakushev I. (2014) Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer’s disease. Alzheimer’s & Dementia 10:684-9.

Yakushev I, Chételat G, Fischer FU, Landeau B, Bastin C, Scheurich A, Perrotin A, Bahri MA, Drzezga A, Eustache F, Schreckenberger M, Fellgiebel A, Salmon E. (2013) Metabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults. Neuroimage 79:184-90.