Responsibilities
Research Group Leader
Contact
Email:
Peter.Meinke@med.uni-muenchen.de
Website:
https://www.lmu-klinikum.de/neurologie/forschung-studien/repeat-kernmembran-und-glykogenspeichererkrankungen-ag-rkg/c84439a3031ec948
Further Information
Keywords:
Neuromuscular Disease; Nuclear Envelope; Repeat Expansion Disease; Glycogen Storage Disease
Research methods:
Transcriptomics; Bioinformatics; Metabolic Measurements; Immunohistochemistry; Primary Tissue Culture; Viral Transduction...
Brief research description:
Work in my group is primarily focused on multisystemic neuromuscular diseases. The focus is on repeat diseases such as myotonic dystrophies (DM) and facioscapulohumeral muscular dystrophy (FSHD); nuclear membrane-associated diseases such as Emery-Dreifuss myopathy (EDMD); and glycogen storage diseases such as Pompe disease. Research ranges from genetic principles, molecular pathomechanisms and biomarker identification to translational therapeutic interventions. Cell culture model systems are established in order to evaluate therapeutic strategies. Specific cellular mechanisms being investigated are splicing mechanisms, cellular metabolism, changes in the nuclear envelope and cellular aging in the context of diseases.
Supervision of current or graduated GSN PhD students:
Hanseul Oh