Graduate School of Systemic Neurosciences GSN-LMU

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Stylianos Michalakis

Prof. Dr. Stylianos Michalakis

GSN associate faculty, regular member MCN


Professor of Ocular Gene Therapy


Department of Pharmacy
Ludwig-Maximilians-Universität München
Butenandtstr. 7
D-81377 Munich


Department of Ophthalmology
Ludwig-Maximilians-Universität München

Phone: +49 (0)89 / 2180-77325
Fax: +49 (0)89 / 2180-77326


Further Information

Research focus: Retinal gene therapy, disease mechanisms and neurodegenerative processes in the retina as well as functional characterization of cyclic nucleotide-gated channels in the CNS

Key words: Gene therapy, retinal degeneration, aav vectors, epigenetics, tet enzymes

GSN students:

Selected publications:

Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S. (2016). Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. Hum Mol Genet. 23:1538-1550.

Perera, A., Eisen D., Wagner, M., Laube, S.K., Künzel, A.F., Koch, S., Steinbacher, J., Schulze, E., Splith, V., Splith, V., Mittermeier, N., Müller, M., Biel, M., Carell, T., Michalakis, S. (2015). TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression. Cell Rep. 11(2):283-94.

Michalakis, S., Shaltiel, L., Sothilingam, V., Koch, S., Schludi, V., Krause, S., Zeitz, C., Audo, I., Lancelot, M.E., Hamel, C., Meunier, I., Preising, M.N., Friedburg, C., Lorenz, B., Zabouri, N., Haverkamp, S., Garrido, M.G., Tanimoto, N., Seeliger, M.W., Biel, M., Wahl-Schott, C.A. (2014). Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2. Hum Mol Genet. 23:1538-1550.

Michalakis, S., Schäferhoff, K., Spiwoks-Becker, I., Zabouri, N., Koch, S., Koch, F., Bonin, M., Biel, M., and Haverkamp, S. (2013). Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction. Cell Mol Life Sci. 70:1831-1847.

Koch, S., Sothilingam, V., Garcia Garrido, M., Tanimoto, N., Becirovic, E., Koch, F., Seide, C., Beck, S.C., Seeliger, M.W., Biel, M., Mühlfriedel, R., and Michalakis, S. (2012). Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Hum Mol Genet. 21:4486-4496.

Michalakis, S., Zong, X., Becirovic, E., Hammelmann, V., Wein, T., Wanner, K.T., and Biel, M. (2011). The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels. J Neurosci. 31:133-141.

Michalakis, S., Mühlfriedel, R., Tanimoto, N., Krishnamoorthy, V., Koch, S., Fischer, M.D., Becirovic, E., Bai, L., Huber, G., Beck, S.C., et al. (2010). Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function. Mol Ther. 18:2057-2063.