Research Group Leader
Keywords: retina organoids, light-sheet microscopy
Research focus: Our team integrates concepts of physics and biology to develop a model system for a retinal neuronal network. The high accessibility and tunability of our in vitro system will allow us to address fundamental questions at the interface between physics and biology: What are the mechanical cues that guide the self-organization of retina tissues? How are light-induced neuronal signals processed within these tissues? Can we use these systems as powerful in vitro disease models? To address these questions we join forces with the soft condensed matter group at the Department of Physics at LMU and the Munich Cluster for Systems Neurology (SyNergy).
GSN Students: Katja Salbaum
1. Serwane F., Mongera A., Rowghanian P., Kealhofer D., Lucio A., Hockenbery Z., Campas O. In vivo quantification of spatially-varying mechanical properties in developing tissues. Nature Methods, 14, 181-186, 2017 Ferrofluid droplets were introduced as mechanical actuators to probe mechanics within living tissues.
2. Mongera A., Gustafson H., Rowghanian P., Shelton E., Kealhofer D., Serwane F., Lucio A., Giammona J., Campas O., A fluid-to-solid jamming transition underlies vertebrate body axis elongation. Nature, 561, 401-405, 2018 The use of magnetic droplets as mechanical actuators revealed a fluid-to-solid transition as physical mechanism to extend the vertebrate body axis.
3. Serwane F., Zürn G., Lompe T., Ottenstein T. B., Wenz A. N., Jochim S., Deterministic preparation of a tunable few-fermion system. Science, Vol. 332. no. 6027, pp. 336-338, 2011 A mesoscopic quantum system with full control over its quantum state was prepared.