Graduate School of Systemic Neurosciences GSN-LMU

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Dr. Kamran Honarnejad

GSN Alumnus SS 2014

Further Information

Thesis Title: Discovery and characterization of novel drugs for treatment of Alzheimer’s Disease from a high-throughput compound screen

Supervisor: Prof. Dr. Jochen Herms


Honarnejad K, Daschner A, Gehring AP, Szybinska A, Giese A, Kuznicki J, Bracher F and Herms J. (2014) Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer’s disease. Transl Psychiatry 4, e489. doi: 10.1038/tp.2014.132.

Honarnejad K, Kirsch AK, Daschner A, Szybinska A, Kuznicki J and Herms J. (2013) FRET-Based Calcium Imaging: A Tool for High-Throughput/Content Phenotypic Drug Screening in Alzheimer Disease. J Biomol Screen 18: 1309. doi: 10.1177/1087057113502672

Honarnejad K, Daschner A, Herms J, Bracher F, Kuznicki J and Gehring AP. (2013) Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging. Pub. No.: WO/2013/139929, International Application No.: PCT/EP2013/055969

Honarnejad K, Jung CKE, Arzberger T, Kretzschmar H and Herms J. (2013) Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer’s disease. J Cell Mol Med. 17(2): 293-302. doi: 10.1111/jcmm.12008

Honarnejad K, Daschner A, Giese A, Zall A, Schmidt B, Szybinska A, Kuznicki and Herms J. (2013) Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease. PLoS ONE 8(11): e80645. doi:10.1371/journal.pone.0080645

Honarnejad K and Herms J. (2012) Presenilins: role in calcium homeostasis. Int J Biochem Cell Biol. 44(11): 1983-6. doi: 10.1016/j.biocel.2012.07.019

Jung CK, Fuhrmann M, Honarnejad K, van Leuven F and Herms J. (2011) Role of Presenilin1 in Structural Plasticity of Cortical Dendritic Spines in vivo. J Neurochem. 119(5): 1064-73. doi: 10.1111/j.1471-4159.2011.07503.x

Honarnejad K, Bojarski L, Kuznicki J and Herms J. (2009) Dysregulated Endoplasmic Reticulum calcium release in Alzheimer's disease: A paradigm for high-throughput drug/siRNA screens. Alzheimer's & Dementia 5(4): 316, ICAD Suppl. doi: 10.1016/j.jalz.2009.04.500

Uhrig M, Brechlin P, Jahn O, Knyazev Y, Weninger A, Busia L, Honarnejad K, Otto M and Hartmann T. (2008) Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Abeta42 reduces their differentiation potential. BMC Med. 6: 38. doi: 10.1186/1741-7015-6-38








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